The 49ers will play the Cardinals on Sunday, January 5th, 2025. The matchup takes place at State Farm Stadium. Watch this exciting Week 18 matchup at 4:25 pm EST. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2024-25 NFL regular season is winding down. One of the upcoming Week 18 matchups includes a battle between the San Francisco 49ers and Arizona Cardinals . Set for Sunday, January 5th, 2025 at State Farm Stadium, the result of this game may affect this season's playoff picture. Take note of each team's performance stats below. Any late-season momentum will likely carryover into the playoffs.
- SportsBetting3.com Power Rankings - Looking at Week 18 of the 2024-25 NFL regular season, the San Francisco 49ers have a 88.33 power ranking based on our formula. The Arizona Cardinals currently possess a 90.33 power ranking as the regular season wraps up.
- Away San Francisco 49ers - The San Francisco 49ers have a 2-5-0 record as an away team for the 2024-25 regular season, ranking them 7th in the league for away team wins.
- Home Arizona Cardinals - As for the Arizona Cardinals, they come to this Week 18 game with a 5-3-0 record as a home team. They rank 4th in the league for home team wins.
- Points Scored - The San Francisco 49ers currently rank 13th (365) as we approach Week 18, with the Arizona Cardinals ranked 15th (353) for points scored to date.
- Points Against - With the regular season concluding, the San Francisco 49ers rank 10th (389) for points score against them. Note that the Arizona Cardinals now rank 18th (355) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. As Week 18 action looms, the San Francisco 49ers have a 6-10-0 record, with the Arizona Cardinals at 7-9-0 for the 2024-25 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast, ye scurvy dogs! The 49ers be settin' sail to face the Cardinals!
The regular season be windin' down, and this be a crucial battle fer both teams.
The game be happenin' at State Farm Stadium, where the Cardinals be lookin' to defend their turf. BetRivers and BetMGM are the best legal NFL sportsbooks, and we've gathered this matchup's prop bets below. Review the best point spread, total, and moneyline odds for this matchup in the following tables.
Best 49ers at Cardinals Odds
| Underdog San Francisco 49ers | Favorite Arizona Cardinals |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Arizona Cardinals |
|---|---|
Matchup Odds FAQs
The Arizona Cardinals are -4.5 -110 point spread favorites at BetMGM, while the San Francisco 49ers are +4.5 -110 point spread underdogs at BetMGM.
The best over line is 42.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 42.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Arizona Cardinals are the -210 moneyline favorite at BetMGM and the San Francisco 49ers are the +170 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Cardinals
1/05/25 4:25pm EST | +4.5 -110-4.5 -110 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A +4.5 San Francisco 49ers underdog bet wins if they lose by 4 or fewer, tie, or win outright. Your bet loses if they lose by 5 or more.
Favorite Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $90.91 at -110 odds.
A -4.5 Arizona Cardinals favorite bet wins if they win by 5 or more. Your bet loses if they win by 4 or fewer, tie, or lose outright.
San Francisco 49ers at Arizona Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Cardinals
First Team To Score
1/05/25 4:25pm EST | +120-155Bet |
49ers
Cardinals
No Touchdown
To Score 1st Touchdown
1/05/25 4:25pm EST | +135-185+8000Bet |
49ers
Cardinals
Game to Overtime
1/05/25 4:25pm EST | Yes +775No -2500Bet |
49ers
Cardinals
Safety to be Scored
1/05/25 4:25pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Joshua Dobbs
Interceptions Thrown
SF at ARI 1/05/25 4:25pm EST | 0.5 o -1100.5 u -120Bet |
Kyler Murray
Interceptions Thrown
SF at ARI 1/05/25 4:25pm EST | 0.5 o +1050.5 u -140Bet |
Joshua Dobbs
Longest Passing Completion
SF at ARI 1/05/25 4:25pm EST | 31.5 o -12031.5 u -110Bet |
Kyler Murray
Longest Passing Completion
SF at ARI 1/05/25 4:25pm EST | 34.5 o -11034.5 u -120Bet |
| BetMGM | |
Chad Ryland
Total Kicking Points
SF at ARI 1/05/25 4:25pm EST | 6.5 o -1206.5 u -110Bet |
Jake Moody
Total Kicking Points
SF at ARI 1/05/25 4:25pm EST | 5.5 o -1355.5 u +100Bet |
Kyler Murray
Total Pass Completions
SF at ARI 1/05/25 4:25pm EST | 21.5 o +10021.5 u -130Bet |
Joshua Dobbs
Total Passing Yards
SF at ARI 1/05/25 4:25pm EST | 195.5 o -115195.5 u -115Bet |
| BetMGM | |
Kyler Murray
Total Passing Yards
SF at ARI 1/05/25 4:25pm EST | 225.5 o -115225.5 u -115Bet |
Joshua Dobbs
Total Touchdown Passes
SF at ARI 1/05/25 4:25pm EST | 1.5 o +1751.5 u -250Bet |
Kyler Murray
Total Touchdown Passes
SF at ARI 1/05/25 4:25pm EST | 1.5 o +1051.5 u -140Bet |
Recent Meetings Since 2020
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Week 18 | 49ers vs Cardinals Sunday, January 5th, 2025 | ARI 47, SF 24 State Farm Stadium | Cardinals by 23 |
| 2024 Week 5 | Cardinals vs 49ers Sunday, October 6th, 2024 | ARI 24, SF 23 Levi's Stadium | Cardinals by 1 |
| 2023 Week 15 | 49ers vs Cardinals Sunday, December 17th, 2023 | SF 45, ARI 29 State Farm Stadium | 49ers by 16 |
| 2023 Week 4 | Cardinals vs 49ers Sunday, October 1st, 2023 | SF 35, ARI 16 Levi's Stadium | 49ers by 19 |
| 2022 Week 18 | Cardinals vs 49ers Sunday, January 8th, 2023 | SF 38, ARI 13 Levi's Stadium | 49ers by 25 |
| 2022 Week 11 | 49ers vs Cardinals Monday, November 21st, 2022 | SF 38, ARI 10 Estadio Azteca | 49ers by 28 |
| 2021 Week 9 | Cardinals vs 49ers Sunday, November 7th, 2021 | ARI 31, SF 17 Levi's Stadium | Cardinals by 14 |
| 2021 Week 5 | 49ers vs Cardinals Sunday, October 10th, 2021 | ARI 17, SF 10 State Farm Stadium | Cardinals by 7 |
| 2020 Week 16 | 49ers vs Cardinals Saturday, December 26th, 2020 | SF 20, ARI 12 State Farm Stadium | 49ers by 8 |
| 2020 Week 1 | Cardinals vs 49ers Sunday, September 13th, 2020 | ARI 24, SF 20 Levi's Stadium | Cardinals by 4 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arizona Cardinals | 8 | 9 | 0 | 0.471 | 400 | 379 | 6-3-0 | 2-6-0 | 3-3-0 | 0.500 | 4-8-0 | 0.333 | 1W | 2-3-0 |
| San Francisco 49ers | 6 | 11 | 0 | 0.353 | 389 | 436 | 4-5-0 | 2-6-0 | 1-5-0 | 0.167 | 4-8-0 | 0.333 | 4L | 1-4-0 |
San Francisco 49ers & Arizona Cardinals Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures OddsNo Super Bowl TM San Francisco 49ers YR: futures available
Arizona Cardinals Futures OddsNo Super Bowl TM Arizona Cardinals YR: futures available
San Francisco 49ers & Arizona Cardinals Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Arizona Cardinals NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, January 5th, 2025 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Arizona Cardinals Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Arizona Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other January 5, 2025 NFL Games
- Washington Commanders vs Dallas Cowboys - 1/05/25 1:02pm EST
- Chicago Bears vs Green Bay Packers - 1/05/25 1:02pm EST
- Jacksonville Jaguars vs Indianapolis Colts - 1/05/25 1:02pm EST
- Carolina Panthers vs Atlanta Falcons - 1/05/25 1:02pm EST
- Houston Texans vs Tennessee Titans - 1/05/25 1:02pm EST
- Buffalo Bills vs New England Patriots - 1/05/25 1:02pm EST
- New Orleans Saints vs Tampa Bay Buccaneers - 1/05/25 1:02pm EST
- New York Giants vs Philadelphia Eagles - 1/05/25 1:03pm EST
- Miami Dolphins vs New York Jets - 1/05/25 4:25pm EST
- Kansas City Chiefs vs Denver Broncos - 1/05/25 4:25pm EST
- Los Angeles Chargers vs Las Vegas Raiders - 1/05/25 4:25pm EST
- Seattle Seahawks vs Los Angeles Rams - 1/05/25 4:25pm EST
- Minnesota Vikings vs Detroit Lions - 1/05/25 8:20pm EST