San Francisco Giants vs Houston Astros Odds

The Giants will play the Astros on Wednesday, April 2nd, 2025. Your timezone's first pitch time is 4:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The San Francisco Giants have a 96.00 power ranking. The power ranking for the Houston Astros is 92.00.
  • Visiting San Francisco Giants - The San Francisco Giants have a 3-1 record as a visiting team, ranking them 1st Overall for visiting team wins.
  • Home Houston Astros - The Houston Astros have a 2-2 record as a home team. They rank 4th for home team wins in the Overall standings.
  • Runs Scored - The San Francisco Giants currently stand 8th (21) Overall, with the Houston Astros ranking 18th (8) for runs scored.
  • Runs Allowed - The San Francisco Giants are 14th (12) Overall for runs allowed. The Houston Astros stand 14th (12) for runs allowed.
  • Team Streaks - The San Francisco Giants have won their last 2 games. Meanwhile, the Houston Astros lost their last game.
  • Team Records - The San Francisco Giants have a 3-1 Overall record (2.0 GB National West Division), with the Houston Astros possessing a 2-2 Overall standing (1.0 GB American West Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye! The Giants be sailin' to Houston with a mighty record... of 3-1, ready to plunder and pillage the Astros on their own turf. (The Astros be standin' at 2-2, not even worth a second glance.)

San Francisco be holdin' a win percentage of 0.750, a force to be reckoned with... while the Astros can barely keep their heads above water at 0.500. (The Giants be showin' no mercy as they continue their winning streak.)

If ye be lookin' to make some doubloons, head over to SportsBetting3.com... and bet on this game. Review the odds below and place yer bets wisely!

Best Giants at Astros Odds


Best Moneyline Betting Odds
Underdog

San Francisco Giants
Favorite

Houston Astros
The Houston Astros are the -170 moneyline favorite. Risk $170 to win $100 on the Houston Astros at BetMGM. The San Francisco Giants are the +140 underdog at BetMGM. Risk $100 to win $140 on the San Francisco Giants. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 7.5 runs. Risk $105 to win $100. BetMGM has the best under line of 7.5 runs. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

San Francisco Giants
Favorite

Houston Astros
The Houston Astros have a -1.5 +125 run line at BetMGM OH. They are the run line favorite in this matchup. The San Francisco Giants have a +1.5 -155 run line at BetMGM OH. The San Francisco Giants are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the San Francisco Giants vs Houston Astros MLB game on Wednesday, April 2nd, 2025?

The Houston Astros are the -170 moneyline favorite at BetMGM and the San Francisco Giants are the +140 moneyline underdog at BetMGM.

What is the over-under total line for the San Francisco Giants vs Houston Astros MLB game on Wednesday, April 2nd, 2025?

The best over line is 7.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 7.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the run line for the San Francisco Giants vs Houston Astros MLB game on Wednesday, April 2nd, 2025?

The Houston Astros are -1.5 +125 run line favorites at BetMGM, while the San Francisco Giants are +1.5 -155 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Giants
Astros
4:10pm EDT
+140-170
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • San Francisco Giants bettors risk $100 to win $140 at +140 odds. The implied probability for San Francisco Giants is 41.67%.
  • Houston Astros bettors risk $100 to win $58.82 at -170 odds. The implied probability for Houston Astros is 62.96%.

San Francisco Giants at Houston Astros Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Giants
Astros
First Team to Score
4:10pm EDT
-115-110Bet
Giants
Astros
Tie
1st Inning Winner
4:10pm EDT
+375+290-160Bet
Giants
Astros
Tie
First 3 Innings Winner
4:10pm EDT
+200+115+240Bet
Giants
Astros
To Extra Innings
4:10pm EDT
Yes +725No -1200Bet
BetMGM Sports Betting BetMGM
Giants
Astros
1st Team to Score Will Win
4:10pm EDT
Yes -250No +190Bet
Astros
Total Runs
SFO at HOU
4:10pm EDT
4.5 o +1154.5 u -150Bet
Giants
Total Runs
SFO at HOU
4:10pm EDT
3.5 o +1103.5 u -145Bet
Framber Valdez
Strikeouts Thrown
SFO at HOU
4:10pm EDT
5.5 o -1605.5 u +120Bet
BetMGM Sports Betting BetMGM
Landen Roupp
Strikeouts Thrown
SFO at HOU
4:10pm EDT
4.5 o +1204.5 u -155Bet

San Francisco Giants & Houston Astros Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

San Francisco Giants World Series Odds
2025 San Francisco Giants World Series Odds

Team
BetMGM Sports Betting BetMGM
Giants
+8000
Bet
Houston Astros World Series Odds
2025 Houston Astros World Series Odds

Team
BetMGM Sports Betting BetMGM
Astros
+2000
Bet

San Francisco Giants & Houston Astros Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - San Francisco Giants, Houston Astros
Team W L Pct GB Home Away RS RA Diff Strk L10
San Francisco Giants310.750+2.00-03-12112+9W23-1
Houston Astros220.500+3.02-20-0812-4L12-2

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco Giants vs Houston Astros MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 2nd, 2025 at 4:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the San Francisco Giants vs Houston Astros Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the San Francisco Giants vs Houston Astros Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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