Buffalo Bills vs San Francisco 49ers Odds

The Bills will play the 49ers on Monday, December 7th, 2020. The matchup takes place at State Farm Stadium. Watch this exciting Week 13 matchup at 8:15 pm EST. Check local listings for coverage on ESPN, ABC.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Best Bills at 49ers Odds


Best Point Spread Betting Odds
TBDTBD
Point Spread odds are updating, please check back soon.

Best Total Betting Odds
OverUnder
Total odds are updating, please check back soon.

Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game Book

Buffalo Bills at San Francisco 49ers Prop Bets

NFL Prop Bets
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BetMGM Sports Betting BetMGM
Bet
Bills
49ers
12/07/20 8:15pm EST
Pending BetMGM

Recent Meetings Since 2016

Recent Meetings Since 2016
WeekGameResultMargin
2024
Week 13
49ers vs Bills
Sunday, December 1st, 2024
BUF 35, SF 10
Highmark Stadium
Bills by 25
2020
Week 13
Bills vs 49ers
Monday, December 7th, 2020
BUF 34, SF 24
State Farm Stadium
Bills by 10
2016
Week 6
49ers vs Bills
Sunday, October 16th, 2016
BUF 45, SF 16
Highmark Stadium
Bills by 29

Team Standings

2020-2021 NFL Regular Season Standings - Buffalo Bills, San Francisco 49ers
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - Buffalo Bills13300.8135013757-1-06-2-06-0-01.00010-2-00.8336W5-0-0
San Francisco 49ers61000.3753763901-7-05-3-03-3-00.5004-8-00.3331L1-4-0

Buffalo Bills & San Francisco 49ers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds
2024-25 Buffalo Bills Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Bills
+450
Bet
San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Buffalo Bills & San Francisco 49ers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs San Francisco 49ers NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Monday, December 7th, 2020 at 8:15 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Buffalo Bills vs San Francisco 49ers Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs San Francisco 49ers Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other December 7, 2020 NFL Games

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