Buffalo Bills vs Detroit Lions Odds

The Bills will play the Lions on Sunday, December 15th, 2024. The matchup takes place at Ford Field. Watch this exciting Week 15 matchup at 4:25 pm EST. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

It's now Week 15, as the 2024-25 NFL regular season is coming to a close. This week's action includes a matchup between the Buffalo Bills and Detroit Lions. They'll play on Sunday, December 15th, 2024 at Ford Field, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.

  • SportsBetting3.com Power Rankings - Now Week 15 of the 2024-25 NFL regular season, the Buffalo Bills have a 96.67 power ranking based on our formula. Their opponent, the Detroit Lions, currently possess a 100.00 power ranking.
  • Away Buffalo Bills - With the season coming to a close, the Buffalo Bills have a 4-3-0 record as an away team, ranking them 3rd in the league for away team wins.
  • Home Detroit Lions - The Detroit Lions come to this Week 15 game with a 6-1-0 record as a home team. They rank 2nd in the league for home team wins as the 2024-25 regular season wraps up.
  • Points Scored - The Buffalo Bills currently rank 2nd (397) headed into Week 15, with the Detroit Lions ranked 1st (417) for points scored to date.
  • Points Against - As the regular season winds down, the Buffalo Bills rank 24th (268) for points score against them. Note that the Detroit Lions now rank 28th (234) for points scored against.
  • Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 15, the Buffalo Bills have a 10-3-0 record, with the Detroit Lions at 12-1-0 for the 2024-25 NFL regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast, ye scallywags! The Bills be sailing to Detroit to plunder victory!

Ye better be watchin' this Week 15 clash - playoff spots be on the line!

Buffalo be standin' at 10-3-0, while Detroit be holdin' a 12-1-0 record.

This battle be goin' down at Ford Field, where the Lions be roarin'!

According to the rankings, the Bills be at 96.67, while the Lions be at 100.00.

So place a bet at BetRivers or BetMGM, and keep an eye on the prop bets!

We've compared odds from our partner sportsbooks, so be sure to look below!

Best Bills at Lions Odds


Best Point Spread Betting Odds
Underdog

Buffalo Bills
Favorite

Detroit Lions
The Detroit Lions have a -2.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. The Buffalo Bills have a +2.5 -110 point spread at BetMGM OH. The Buffalo Bills are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 54.5 points. Risk $110 to win $100. BetMGM has the best under line of 54.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Buffalo Bills
Favorite

Detroit Lions
The Detroit Lions are the -135 moneyline favorite. Risk $135 to win $100 on the Detroit Lions at BetMGM. The Buffalo Bills are the +110 underdog at BetMGM. Risk $100 to win $110 on the Buffalo Bills. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Buffalo Bills vs Detroit Lions NFL game on Sunday, December 15th, 2024?

The Detroit Lions are -2.5 -110 point spread favorites at BetMGM, while the Buffalo Bills are +2.5 -110 point spread underdogs at BetMGM.

What is the over-under total line for the Buffalo Bills vs Detroit Lions NFL game on Sunday, December 15th, 2024?

The best over line is 54.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 54.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Buffalo Bills vs Detroit Lions NFL game on Sunday, December 15th, 2024?

The Detroit Lions are the -135 moneyline favorite at BetMGM and the Buffalo Bills are the +110 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Bills
Lions
12/15/24 4:25pm EST
+2.5 -110-2.5 -110
Bet $100 at BetMGM Ohio
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Underdog Buffalo Bills - Buffalo Bills bettors risk $100 to win $90.91 at -110 odds.

A +2.5 Buffalo Bills underdog bet wins if they lose by 2 or fewer, tie, or win outright. Your bet loses if they lose by 3 or more.

Favorite Detroit Lions - Detroit Lions bettors risk $100 to win $90.91 at -110 odds.

A -2.5 Detroit Lions favorite bet wins if they win by 3 or more. Your bet loses if they win by 2 or fewer, tie, or lose outright.

Buffalo Bills at Detroit Lions Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Bills
Lions
First Team To Score
12/15/24 4:25pm EST
+100-130Bet
Bills
Lions
No Touchdown
To Score 1st Touchdown
12/15/24 4:25pm EST
+100-135+10000Bet
Bills
Lions
Game to Overtime
12/15/24 4:25pm EST
Yes +675No -2000Bet
Bills
Lions
Safety to be Scored
12/15/24 4:25pm EST
Yes +1000No -3000Bet
BetMGM Sports Betting BetMGM
Jared Goff
Interceptions Thrown
BUF at DET
12/15/24 4:25pm EST
0.5 o -1050.5 u -125Bet
Josh Allen
Interceptions Thrown
BUF at DET
12/15/24 4:25pm EST
0.5 o -1200.5 u -110Bet
Jared Goff
Longest Passing Completion
BUF at DET
12/15/24 4:25pm EST
34.5 o -11034.5 u -120Bet
Josh Allen
Longest Passing Completion
BUF at DET
12/15/24 4:25pm EST
38.5 o -11038.5 u -120Bet
BetMGM Sports Betting BetMGM
Jake Bates
Total Kicking Points
BUF at DET
12/15/24 4:25pm EST
7.5 o -1307.5 u -105Bet
Tyler Bass
Total Kicking Points
BUF at DET
12/15/24 4:25pm EST
7.5 o +1107.5 u -150Bet
Jared Goff
Total Pass Completions
BUF at DET
12/15/24 4:25pm EST
23.5 o -12023.5 u -110Bet
Josh Allen
Total Pass Completions
BUF at DET
12/15/24 4:25pm EST
22.5 o -11022.5 u -120Bet
BetMGM Sports Betting BetMGM
Jared Goff
Total Passing Yards
BUF at DET
12/15/24 4:25pm EST
260.5 o -115260.5 u -115Bet
Josh Allen
Total Passing Yards
BUF at DET
12/15/24 4:25pm EST
257.5 o -115257.5 u -115Bet
Jared Goff
Total Touchdown Passes
BUF at DET
12/15/24 4:25pm EST
1.5 o -1651.5 u +125Bet
Josh Allen
Total Touchdown Passes
BUF at DET
12/15/24 4:25pm EST
1.5 o -1451.5 u +110Bet

Recent Meetings Since 2020

Recent Meetings Since 2020
WeekGameResultMargin
2024
Week 15
Bills vs Lions
Sunday, December 15th, 2024
BUF 48, DET 42
Ford Field
Bills by 6
2022
Week 12
Bills vs Lions
Thursday, November 24th, 2022
BUF 28, DET 25
Ford Field
Bills by 3
2021
Preseason Week 1
Bills vs Lions
Friday, August 13th, 2021
BUF 16, DET 15
Ford Field
Bills by 1

Team Standings

2024-2025 NFL Regular Season Standings - Buffalo Bills, Detroit Lions
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
x - Detroit Lions13200.8674932996-2-07-0-05-0-01.0009-1-00.9001W4-1-0
xz - Buffalo Bills12300.8004693317-0-05-3-04-0-01.0008-2-00.8002W4-1-0

Buffalo Bills & Detroit Lions Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Buffalo Bills Futures Odds
2024-25 Buffalo Bills Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Bills
+450
Bet
Detroit Lions Futures Odds
2024-25 Detroit Lions Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Lions
+425
Bet

Buffalo Bills & Detroit Lions Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Buffalo Bills vs Detroit Lions NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 15th, 2024 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Detroit Lions Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Detroit Lions Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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