Arizona Cardinals vs Buffalo Bills Odds

The Cardinals will play the Bills on Sunday, September 8th, 2024. The matchup takes place at Highmark Stadium. Watch this exciting Week 1 matchup at 1:00 pm EDT. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


Bonus
BetMGM Sportsbook#1 BetMGM
REVIEW
New Customers - Up to $1500 Paid Back in Bonus Bets
Bonus Bets Expire in 7 Days
One new customer offer/Add'l Terms

Bet Now
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Table of Contents

Key Matchup Stats

It's early in the 2024-25 NFL regular season for the Arizona Cardinals and Buffalo Bills. Let's review some stats from the 2023 regular season to get an idea of how these teams will fare.

  • SportsBetting3.com Power Rankings - The Arizona Cardinals had a 87.33 power ranking in the 2023 regular season. The power ranking for the Buffalo Bills in the 2023 regular season was 98.33.
  • Away Arizona Cardinals - At the end of the 2023 regular season, the Arizona Cardinals had a 2-7-0 record as an away team, ranking them 6th in the regular season for away team wins.
  • Home Buffalo Bills - The Buffalo Bills finished the 2023 regular season with a 7-2-0 record as a home team. They ranked 2nd for home team wins in the regular season standings.
  • Points Scored - The Arizona Cardinals wound up 22nd (330) in the regular season, with the Buffalo Bills ranked 6th (451) for points scored in the 2023 regular season.
  • Points Against - The Arizona Cardinals finished 2nd (455) in the regular season for points against. The Buffalo Bills wound up 28th (311) in the 2023 regular season for points against.
  • Team Records - The Arizona Cardinals had a 4-13-0 regular season record, with the Buffalo Bills notching a 11-6-0 regular season standing last year.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The Arizona Cardinals be sailin' to Highmark Stadium to battle the Bills. The Cardinals be lookin' to plunder a win after a dismal season.

But beware, the Bills be a fierce foe, with a strong record last season. The battle between these two teams be sure to be a nail-biter.

If ye be feelin' lucky, head over to SportsBetting3.com to bet on this game. Ye can review the odds below and put yer doubloons on the line. May the best team win on the gridiron!

Best Cardinals at Bills Odds


Best Point Spread Betting Odds
Underdog

Arizona Cardinals
Favorite

Buffalo Bills
The Buffalo Bills have a -6.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. The Arizona Cardinals have a +6.5 -105 point spread at BetMGM OH. The Arizona Cardinals are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 46 points. Risk $110 to win $100. BetMGM has the best under line of 46 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Arizona Cardinals
Favorite

Buffalo Bills
The Buffalo Bills are the -300 moneyline favorite. Risk $300 to win $100 on the Buffalo Bills at BetMGM. The Arizona Cardinals are the +240 underdog at BetMGM. Risk $100 to win $240 on the Arizona Cardinals. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Arizona Cardinals vs Buffalo Bills NFL game on Sunday, September 8th, 2024?

The Buffalo Bills are -6.5 -115 point spread favorites at BetMGM, while the Arizona Cardinals are +6.5 -105 point spread underdogs at BetMGM.

What is the over-under total line for the Arizona Cardinals vs Buffalo Bills NFL game on Sunday, September 8th, 2024?

The best over line is 46 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 46 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Arizona Cardinals vs Buffalo Bills NFL game on Sunday, September 8th, 2024?

The Buffalo Bills are the -300 moneyline favorite at BetMGM and the Arizona Cardinals are the +240 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Cardinals
Bills
9/08/24 1:00pm EDT
+6.5 -105-6.5 -115
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Underdog Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $95.24 at -105 odds.

A +6.5 Arizona Cardinals underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.

Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $86.96 at -115 odds.

A -6.5 Buffalo Bills favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.

Arizona Cardinals at Buffalo Bills Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Cardinals
Bills
First Team To Score
9/08/24 1:00pm EDT
+135-175Bet
Cardinals
Bills
No Touchdown
To Score 1st Touchdown
9/08/24 1:00pm EDT
+145-200+10000Bet
Cardinals
Bills
Game to Overtime
9/08/24 1:00pm EDT
Yes +800No -3000Bet
Cardinals
Bills
Safety to be Scored
9/08/24 1:00pm EDT
Yes +1000No -3000Bet
BetMGM Sports Betting BetMGM
Cardinals
Team Total Points
ARI at BUF
9/08/24 1:00pm EDT
21.5 o +11021.5 u -145Bet
Bills
Team Total Points
ARI at BUF
9/08/24 1:00pm EDT
27.5 o +10027.5 u -125Bet
Josh Allen
Interceptions Thrown
ARI at BUF
9/08/24 1:00pm EDT
0.5 o -1100.5 u -120Bet
Kyler Murray
Interceptions Thrown
ARI at BUF
9/08/24 1:00pm EDT
0.5 o -1350.5 u +100Bet
BetMGM Sports Betting BetMGM
Josh Allen
Longest Passing Completion
ARI at BUF
9/08/24 1:00pm EDT
35.5 o -12035.5 u -110Bet
Kyler Murray
Longest Passing Completion
ARI at BUF
9/08/24 1:00pm EDT
33.5 o -11533.5 u -120Bet
Matt Prater
Total Kicking Points
ARI at BUF
9/08/24 1:00pm EDT
5.5 o -1255.5 u -105Bet
Tyler Bass
Total Kicking Points
ARI at BUF
9/08/24 1:00pm EDT
7.5 o +1057.5 u -140Bet
BetMGM Sports Betting BetMGM
Kyler Murray
Total Pass Completions
ARI at BUF
9/08/24 1:00pm EDT
21.5 o -12521.5 u -105Bet
Josh Allen
Total Passing Yards
ARI at BUF
9/08/24 1:00pm EDT
244.5 o -115244.5 u -115Bet
Kyler Murray
Total Passing Yards
ARI at BUF
9/08/24 1:00pm EDT
225.5 o -115225.5 u -115Bet
Josh Allen
Total Touchdown Passes
ARI at BUF
9/08/24 1:00pm EDT
1.5 o -1251.5 u -105Bet
BetMGM Sports Betting BetMGM
Kyler Murray
Total Touchdown Passes
ARI at BUF
9/08/24 1:00pm EDT
1.5 o +1201.5 u -160Bet

Recent Meetings Since 2020

Recent Meetings Since 2020
WeekGameResultMargin
2024
Week 1
Cardinals vs Bills
Sunday, September 8th, 2024
BUF 34, ARI 28
Highmark Stadium
Bills by 6
2020
Week 10
Bills vs Cardinals
Sunday, November 15th, 2020
ARI 32, BUF 30
State Farm Stadium
Cardinals by 2

Team Standings

2024-2025 NFL Regular Season Standings - Arizona Cardinals, Buffalo Bills
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
xz - Buffalo Bills12300.8004693317-0-05-3-04-0-01.0008-2-00.8002W4-1-0
Arizona Cardinals7800.4673443425-3-02-5-02-2-00.5003-7-00.3001L1-4-0

Arizona Cardinals & Buffalo Bills Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Arizona Cardinals Futures Odds
2024-25 Arizona Cardinals Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Cardinals
+25000
Bet
Buffalo Bills Futures Odds
2024-25 Buffalo Bills Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Bills
+450
Bet

Arizona Cardinals & Buffalo Bills Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Arizona Cardinals vs Buffalo Bills NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 8th, 2024 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs Buffalo Bills Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs Buffalo Bills Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 8, 2024 NFL Games

Odds Preview 1340