The Cardinals will play the Blue Devils on Thursday, November 18th, 2021. The matchup takes place at Wallace Wade Stadium. Watch this exciting Week 12 matchup at 7:30 pm EST. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Best Cardinals at Blue Devils Odds
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| Over | Under |
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College Football Odds Example
| Game | Book |
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Louisville at Duke Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
 BetMGMBet |
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Louisville
Duke
11/18/21 7:30pm EST | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2023 Week 9 | Duke vs Louisville Saturday, October 28th, 2023 | LOU 23, DUKE 0 Cardinal Stadium | Louisville by 23 |
| 2021 Week 12 | Louisville vs Duke Thursday, November 18th, 2021 | LOU 62, DUKE 22 Wallace Wade Stadium | Louisville by 40 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| ACC Atlantic | |||||||||
| Louisville | 4-4 | 0.500 | 6 | 7 | 411 | 355 | 4-3 | 2-2 | L2 |
| ACC Coastal | |||||||||
| Duke | 0-8 | 0.000 | 3 | 9 | 274 | 477 | 3-4 | 0-5 | L8 |
Louisville & Duke Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Louisville Championship Odds|
Team | BetMGM |
|---|---|
| Louisville |
No NCAA College Football Championship TM Duke YR: futures available
Louisville & Duke Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Louisville vs Ole Miss | MISS 43, LOU 24 Monday, September 6th, 2021 |
| Week 2 | Eastern Kentucky vs Louisville | LOU 30, EKU 3 Saturday, September 11th, 2021 |
| Week 3 | UCF vs Louisville | LOU 42, UCF 35 Friday, September 17th, 2021 |
| Week 4 | Louisville vs Florida State | LOU 31, FSU 23 Saturday, September 25th, 2021 |
| Week 5 | Louisville vs Wake Forest | WAKE 37, LOU 34 Saturday, October 2nd, 2021 |
| Week 6 | Virginia vs Louisville | UVA 34, LOU 33 Saturday, October 9th, 2021 |
| Week 8 | Boston College vs Louisville | LOU 28, BC 14 Saturday, October 23rd, 2021 |
| Week 9 | Louisville vs NC State | NCST 28, LOU 13 Saturday, October 30th, 2021 |
| Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
| Week 11 | Syracuse vs Louisville | LOU 41, SYR 3 Saturday, November 13th, 2021 |
| Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
| Week 13 | Kentucky vs Louisville | UK 52, LOU 21 Saturday, November 27th, 2021 |
| Bowls | Air Force vs Louisville Servpro First Responder Bowl | AFA 31, LOU 28 Tuesday, December 28th, 2021 |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Duke vs Charlotte | CLT 31, DUKE 28 Friday, September 3rd, 2021 |
| Week 2 | North Carolina A&T vs Duke | DUKE 45, NCAT 17 Friday, September 10th, 2021 |
| Week 3 | Northwestern vs Duke | DUKE 30, NU 23 Saturday, September 18th, 2021 |
| Week 4 | Kansas vs Duke | DUKE 52, KU 33 Saturday, September 25th, 2021 |
| Week 5 | Duke vs North Carolina | UNC 38, DUKE 7 Saturday, October 2nd, 2021 |
| Week 6 | Georgia Tech vs Duke | GT 31, DUKE 27 Saturday, October 9th, 2021 |
| Week 7 | Duke vs Virginia | UVA 48, DUKE 0 Saturday, October 16th, 2021 |
| Week 9 | Duke vs Wake Forest | WAKE 45, DUKE 7 Saturday, October 30th, 2021 |
| Week 10 | Pittsburgh vs Duke | PITT 54, DUKE 29 Saturday, November 6th, 2021 |
| Week 11 | Duke vs Virginia Tech | VT 48, DUKE 17 Saturday, November 13th, 2021 |
| Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
| Week 13 | Miami (FL) vs Duke | MIA 47, DUKE 10 Saturday, November 27th, 2021 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Louisville vs Duke College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, November 18th, 2021 at 7:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Louisville vs Duke Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Louisville vs Duke Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.