The Cyclones will play the Tigers on Wednesday, December 29th, 2021, in the annual Cheez-It Bowl event. The matchup takes place at Camping World Stadium. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Best Cyclones at Tigers Odds
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| Over | Under |
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| TBD | TBD |
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College Football Odds Example
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Iowa State at Clemson Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
 BetMGMBet |
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Iowa State
Clemson
12/29/21 5:50pm EST | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2021 Bowls | Clemson vs Iowa State Wednesday, December 29th, 2021 Cheez-It Bowl | CLEM 20, ISU 13 Camping World Stadium | Clemson by 7 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| ACC Atlantic | |||||||||
| #14 Clemson | 6-2 | 0.750 | 10 | 3 | 342 | 193 | 6-0 | 3-2 | W6 |
| Big 12 | |||||||||
| Iowa State | 5-4 | 0.556 | 7 | 6 | 407 | 267 | 5-1 | 2-4 | L1 |
Iowa State & Clemson Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Iowa State Championship Odds|
Team | BetMGM |
|---|---|
| Iowa State | +25000 Bet |
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Team | BetMGM |
|---|---|
| Clemson | +5000 Bet |
Iowa State & Clemson Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Northern Iowa vs Iowa State | ISU 16, UNI 10 Saturday, September 4th, 2021 |
| Week 2 | Iowa vs Iowa State | IOWA 27, ISU 17 Saturday, September 11th, 2021 |
| Week 3 | Iowa State vs UNLV | ISU 48, UNLV 3 Saturday, September 18th, 2021 |
| Week 4 | Iowa State vs Baylor | BAY 31, ISU 29 Saturday, September 25th, 2021 |
| Week 5 | Kansas vs Iowa State | ISU 59, KU 7 Saturday, October 2nd, 2021 |
| Week 7 | Iowa State vs Kansas State | ISU 33, KSU 20 Saturday, October 16th, 2021 |
| Week 8 | Oklahoma State vs Iowa State | ISU 24, OKST 21 Saturday, October 23rd, 2021 |
| Week 9 | Iowa State vs West Virginia | WVU 38, ISU 31 Saturday, October 30th, 2021 |
| Week 10 | Texas vs Iowa State | ISU 30, TEX 7 Saturday, November 6th, 2021 |
| Week 11 | Iowa State vs Texas Tech | TTU 41, ISU 38 Saturday, November 13th, 2021 |
| Week 12 | Iowa State vs Oklahoma | OU 28, ISU 21 Saturday, November 20th, 2021 |
| Week 13 | TCU vs Iowa State | ISU 48, TCU 14 Friday, November 26th, 2021 |
| Bowls | Clemson vs Iowa State Cheez-It Bowl | CLEM 20, ISU 13 Wednesday, December 29th, 2021 |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Georgia vs Clemson | UGA 10, CLEM 3 Saturday, September 4th, 2021 |
| Week 2 | South Carolina State vs Clemson | CLEM 49, SCST 3 Saturday, September 11th, 2021 |
| Week 3 | Georgia Tech vs Clemson | CLEM 14, GT 8 Saturday, September 18th, 2021 |
| Week 4 | Clemson vs NC State | NCST 27, CLEM 21 (2OT) Saturday, September 25th, 2021 |
| Week 5 | Boston College vs Clemson | CLEM 19, BC 13 Saturday, October 2nd, 2021 |
| Week 7 | Clemson vs Syracuse | CLEM 17, SYR 14 Friday, October 15th, 2021 |
| Week 8 | Clemson vs Pittsburgh | PITT 27, CLEM 17 Saturday, October 23rd, 2021 |
| Week 9 | Florida State vs Clemson | CLEM 30, FSU 20 Saturday, October 30th, 2021 |
| Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
| Week 11 | UConn vs Clemson | CLEM 44, CONN 7 Saturday, November 13th, 2021 |
| Week 12 | Wake Forest vs Clemson | CLEM 48, WAKE 27 Saturday, November 20th, 2021 |
| Week 13 | Clemson vs South Carolina | CLEM 30, SC 0 Saturday, November 27th, 2021 |
| Bowls | Clemson vs Iowa State Cheez-It Bowl | CLEM 20, ISU 13 Wednesday, December 29th, 2021 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Iowa State vs Clemson College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, December 29th, 2021 at 5:50 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Iowa State vs Clemson Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Iowa State vs Clemson Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.