The Tigers will play the Cardinals on Saturday, November 6th, 2021. The matchup takes place at Cardinal Stadium. Watch this exciting Week 10 matchup at 7:30 pm EDT. Check local listings for coverage on ACCN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Best Tigers at Cardinals Odds

**Best Point Spread Betting Odds**
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Clemson at Louisville Prop Bets

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College Football Prop Bets
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	BetMGM Bet
Clemson Louisville 11/06/21 7:30pm EDT	Pending BetMGM

Recent Meetings Since 2017

Recent Meetings Since 2017
Week	Game	Result	Margin
2024 Week 10	Louisville vs Clemson Saturday, November 2nd, 2024	LOU 33, CLEM 21 Memorial Stadium (Clemson, SC)	Louisville by 12
2022 Week 11	Louisville vs Clemson Saturday, November 12th, 2022	CLEM 31, LOU 16 Memorial Stadium (Clemson, SC)	Clemson by 15
2021 Week 10	Clemson vs Louisville Saturday, November 6th, 2021	CLEM 30, LOU 24 Cardinal Stadium	Clemson by 6
2019 Week 8	Clemson vs Louisville Saturday, October 19th, 2019	CLEM 45, LOU 10 Cardinal Stadium	Clemson by 35
2018 Week 10	Louisville vs Clemson Saturday, November 3rd, 2018	CLEM 77, LOU 16 Memorial Stadium (Clemson, SC)	Clemson by 61
2017 Week 3	Clemson vs Louisville Saturday, September 16th, 2017	CLEM 47, LOU 21 Cardinal Stadium	Clemson by 26

Team Standings

2021-2022 College Football Regular Season Standings - Clemson, Louisville
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
#14 Clemson	6-2	0.750	10	3	342	193	6-0	3-2	W6
Louisville	4-4	0.500	6	7	411	355	4-3	2-2	L2

Clemson & Louisville Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Clemson Championship Odds

No NCAA College Football Championship TM Clemson YR: futures available

Louisville Championship Odds

No NCAA College Football Championship TM Louisville YR: futures available

Clemson & Louisville Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2021-22 Clemson Games & Results
Week	Matchup	Date & Result
Week 1	Georgia vs Clemson	UGA 10, CLEM 3 Saturday, September 4th, 2021
Week 2	South Carolina State vs Clemson	CLEM 49, SCST 3 Saturday, September 11th, 2021
Week 3	Georgia Tech vs Clemson	CLEM 14, GT 8 Saturday, September 18th, 2021
Week 4	Clemson vs NC State	NCST 27, CLEM 21 (2OT) Saturday, September 25th, 2021
Week 5	Boston College vs Clemson	CLEM 19, BC 13 Saturday, October 2nd, 2021
Week 7	Clemson vs Syracuse	CLEM 17, SYR 14 Friday, October 15th, 2021
Week 8	Clemson vs Pittsburgh	PITT 27, CLEM 17 Saturday, October 23rd, 2021
Week 9	Florida State vs Clemson	CLEM 30, FSU 20 Saturday, October 30th, 2021
Week 10	Clemson vs Louisville	CLEM 30, LOU 24 Saturday, November 6th, 2021
Week 11	UConn vs Clemson	CLEM 44, CONN 7 Saturday, November 13th, 2021
Week 12	Wake Forest vs Clemson	CLEM 48, WAKE 27 Saturday, November 20th, 2021
Week 13	Clemson vs South Carolina	CLEM 30, SC 0 Saturday, November 27th, 2021
Bowls	Clemson vs Iowa State Cheez-It Bowl	CLEM 20, ISU 13 Wednesday, December 29th, 2021

2021-22 Louisville Games & Results
Week	Matchup	Date & Result
Week 1	Louisville vs Ole Miss	MISS 43, LOU 24 Monday, September 6th, 2021
Week 2	Eastern Kentucky vs Louisville	LOU 30, EKU 3 Saturday, September 11th, 2021
Week 3	UCF vs Louisville	LOU 42, UCF 35 Friday, September 17th, 2021
Week 4	Louisville vs Florida State	LOU 31, FSU 23 Saturday, September 25th, 2021
Week 5	Louisville vs Wake Forest	WAKE 37, LOU 34 Saturday, October 2nd, 2021
Week 6	Virginia vs Louisville	UVA 34, LOU 33 Saturday, October 9th, 2021
Week 8	Boston College vs Louisville	LOU 28, BC 14 Saturday, October 23rd, 2021
Week 9	Louisville vs NC State	NCST 28, LOU 13 Saturday, October 30th, 2021
Week 10	Clemson vs Louisville	CLEM 30, LOU 24 Saturday, November 6th, 2021
Week 11	Syracuse vs Louisville	LOU 41, SYR 3 Saturday, November 13th, 2021
Week 12	Louisville vs Duke	LOU 62, DUKE 22 Thursday, November 18th, 2021
Week 13	Kentucky vs Louisville	UK 52, LOU 21 Saturday, November 27th, 2021
Bowls	Air Force vs Louisville Servpro First Responder Bowl	AFA 31, LOU 28 Tuesday, December 28th, 2021

How to Bet on the Game

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How to Bet on the Clemson vs Louisville College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 6th, 2021 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Clemson vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Clemson vs Louisville Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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