The Tigers will play the Cardinals on Saturday, November 6th, 2021. The matchup takes place at Cardinal Stadium. Watch this exciting Week 10 matchup at 7:30 pm EDT. Check local listings for coverage on ACCN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Best Tigers at Cardinals Odds
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| Over | Under |
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College Football Odds Example
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Clemson at Louisville Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
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Clemson
Louisville
11/06/21 7:30pm EDT | Pending BetMGM |
Recent Meetings Since 2017
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Week 10 | Louisville vs Clemson Saturday, November 2nd, 2024 | LOU 33, CLEM 21 Memorial Stadium (Clemson, SC) | Louisville by 12 |
| 2022 Week 11 | Louisville vs Clemson Saturday, November 12th, 2022 | CLEM 31, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 15 |
| 2021 Week 10 | Clemson vs Louisville Saturday, November 6th, 2021 | CLEM 30, LOU 24 Cardinal Stadium | Clemson by 6 |
| 2019 Week 8 | Clemson vs Louisville Saturday, October 19th, 2019 | CLEM 45, LOU 10 Cardinal Stadium | Clemson by 35 |
| 2018 Week 10 | Louisville vs Clemson Saturday, November 3rd, 2018 | CLEM 77, LOU 16 Memorial Stadium (Clemson, SC) | Clemson by 61 |
| 2017 Week 3 | Clemson vs Louisville Saturday, September 16th, 2017 | CLEM 47, LOU 21 Cardinal Stadium | Clemson by 26 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #14 Clemson | 6-2 | 0.750 | 10 | 3 | 342 | 193 | 6-0 | 3-2 | W6 |
| Louisville | 4-4 | 0.500 | 6 | 7 | 411 | 355 | 4-3 | 2-2 | L2 |
Clemson & Louisville Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Clemson Championship Odds|
Team | BetMGM |
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| Clemson | +5000 Bet |
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Team | BetMGM |
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| Louisville |
Clemson & Louisville Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Georgia vs Clemson | UGA 10, CLEM 3 Saturday, September 4th, 2021 |
| Week 2 | South Carolina State vs Clemson | CLEM 49, SCST 3 Saturday, September 11th, 2021 |
| Week 3 | Georgia Tech vs Clemson | CLEM 14, GT 8 Saturday, September 18th, 2021 |
| Week 4 | Clemson vs NC State | NCST 27, CLEM 21 (2OT) Saturday, September 25th, 2021 |
| Week 5 | Boston College vs Clemson | CLEM 19, BC 13 Saturday, October 2nd, 2021 |
| Week 7 | Clemson vs Syracuse | CLEM 17, SYR 14 Friday, October 15th, 2021 |
| Week 8 | Clemson vs Pittsburgh | PITT 27, CLEM 17 Saturday, October 23rd, 2021 |
| Week 9 | Florida State vs Clemson | CLEM 30, FSU 20 Saturday, October 30th, 2021 |
| Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
| Week 11 | UConn vs Clemson | CLEM 44, CONN 7 Saturday, November 13th, 2021 |
| Week 12 | Wake Forest vs Clemson | CLEM 48, WAKE 27 Saturday, November 20th, 2021 |
| Week 13 | Clemson vs South Carolina | CLEM 30, SC 0 Saturday, November 27th, 2021 |
| Bowls | Clemson vs Iowa State Cheez-It Bowl | CLEM 20, ISU 13 Wednesday, December 29th, 2021 |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Louisville vs Ole Miss | MISS 43, LOU 24 Monday, September 6th, 2021 |
| Week 2 | Eastern Kentucky vs Louisville | LOU 30, EKU 3 Saturday, September 11th, 2021 |
| Week 3 | UCF vs Louisville | LOU 42, UCF 35 Friday, September 17th, 2021 |
| Week 4 | Louisville vs Florida State | LOU 31, FSU 23 Saturday, September 25th, 2021 |
| Week 5 | Louisville vs Wake Forest | WAKE 37, LOU 34 Saturday, October 2nd, 2021 |
| Week 6 | Virginia vs Louisville | UVA 34, LOU 33 Saturday, October 9th, 2021 |
| Week 8 | Boston College vs Louisville | LOU 28, BC 14 Saturday, October 23rd, 2021 |
| Week 9 | Louisville vs NC State | NCST 28, LOU 13 Saturday, October 30th, 2021 |
| Week 10 | Clemson vs Louisville | CLEM 30, LOU 24 Saturday, November 6th, 2021 |
| Week 11 | Syracuse vs Louisville | LOU 41, SYR 3 Saturday, November 13th, 2021 |
| Week 12 | Louisville vs Duke | LOU 62, DUKE 22 Thursday, November 18th, 2021 |
| Week 13 | Kentucky vs Louisville | UK 52, LOU 21 Saturday, November 27th, 2021 |
| Bowls | Air Force vs Louisville Servpro First Responder Bowl | AFA 31, LOU 28 Tuesday, December 28th, 2021 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Clemson vs Louisville College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 6th, 2021 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Clemson vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Clemson vs Louisville Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 6, 2021 NCAAFB Games
- Army vs Air Force
- Wake Forest vs North Carolina
- Missouri vs Georgia
- SMU vs Memphis
- Illinois vs Minnesota
- Ohio State vs Nebraska
- Kansas State vs Kansas
- Duquesne vs LIU
- Sacred Heart vs St. Francis (PA)
- Liberty vs Ole Miss
- Stony Brook vs Maine
- Louisiana Tech vs UAB
- Alcorn State vs Bethune-Cookman
- Kennesaw State vs Robert Morris
- Drake vs Marist
- Yale vs Brown
- Pittsburgh vs Duke
- Merrimack College vs Wagner
- Georgia Tech vs Miami (FL)
- Fordham vs Georgetown
- Lafayette vs Holy Cross
- South Dakota vs Western Illinois
- William & Mary vs Delaware
- Gardner-Webb vs Hampton
- Lehigh vs Bucknell
- VMI vs East Tennessee State
- Nicholls vs McNeese State
- Northern Iowa vs Illinois State
- Youngstown State vs North Dakota
- Missouri State vs Southern Illinois
- North Alabama vs Monmouth
- Dayton vs Stetson
- Dixie State vs Sam Houston State
- New Hampshire vs Albany
- Furman vs Western Carolina
- Towson vs Richmond
- Presbyterian vs Valparaiso
- Howard vs South Carolina State
- Villanova vs Elon
- Texas Southern vs Jackson State
- Montana vs Northern Colorado
- Tennessee Tech vs Murray State
- Miss Valley State vs Alabama A&M
- Appalachian State vs Arkansas State
- Abilene Christian vs Jacksonville State
- Temple vs East Carolina
- North Dakota State vs South Dakota State
- Portland State vs Weber State
- Eastern Illinois vs Austin Peay
- Southeastern Louisiana vs Incarnate Word
- Alabama State vs Prairie View A&M
- California vs Arizona
- Grambling State vs Arkansas-Pine Bluff
- North Texas vs Southern Miss
- Louisiana-Monroe vs Texas State
- The Citadel vs Samford
- Michigan State vs Purdue
- Campbell vs James Madison
- Wisconsin vs Rutgers
- Tulsa vs Cincinnati
- Baylor vs TCU
- Penn State vs Maryland
- Navy vs Notre Dame
- South Alabama vs Troy
- Rice vs Charlotte
- Oklahoma State vs West Virginia
- Auburn vs Texas A&M
- Colorado State vs Wyoming
- Rhode Island vs UMass
- Idaho State vs BYU
- Middle Tennessee vs Western Kentucky
- UC Davis vs Northern Arizona
- Tulane vs UCF
- NC State vs Florida State
- Utah State vs New Mexico State
- Morehead State vs San Diego
- Mississippi State vs Arkansas
- Houston Baptist vs Northwestern State
- Southern Utah vs Idaho
- Eastern Kentucky vs Stephen F. Austin
- Marshall vs Florida Atlantic
- Coastal Carolina vs Georgia Southern
- LSU vs Alabama
- Iowa vs Northwestern
- Florida A&M vs Southern
- UNLV vs New Mexico
- Tennessee vs Kentucky
- Boise State vs Fresno State
- Old Dominion vs FIU
- Oregon State vs Colorado
- Lamar vs Tarleton
- Indiana vs Michigan
- Houston vs South Florida
- Florida vs South Carolina
- Texas vs Iowa State
- Oregon vs Washington
- San Jose State vs Nevada
- UTSA vs UTEP
- USC vs Arizona State
- San Diego State vs Hawaii