Clemson vs Louisville Football Odds

The Tigers will play the Cardinals on Saturday, November 6th, 2021. The matchup takes place at Cardinal Stadium. Watch this exciting Week 10 matchup at 7:30 pm EDT. Check local listings for coverage on ACCN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Best Tigers at Cardinals Odds


Best Point Spread Betting Odds
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Point Spread odds are updating, please check back soon.

Best Total Betting Odds
OverUnder
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Best Moneyline Betting Odds
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Clemson at Louisville Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

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Clemson
Louisville
11/06/21 7:30pm EDT
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Recent Meetings Since 2017

Recent Meetings Since 2017
WeekGameResultMargin
2024
Week 10
Louisville vs Clemson
Saturday, November 2nd, 2024
LOU 33, CLEM 21
Memorial Stadium (Clemson, SC)
Louisville by 12
2022
Week 11
Louisville vs Clemson
Saturday, November 12th, 2022
CLEM 31, LOU 16
Memorial Stadium (Clemson, SC)
Clemson by 15
2021
Week 10
Clemson vs Louisville
Saturday, November 6th, 2021
CLEM 30, LOU 24
Cardinal Stadium
Clemson by 6
2019
Week 8
Clemson vs Louisville
Saturday, October 19th, 2019
CLEM 45, LOU 10
Cardinal Stadium
Clemson by 35
2018
Week 10
Louisville vs Clemson
Saturday, November 3rd, 2018
CLEM 77, LOU 16
Memorial Stadium (Clemson, SC)
Clemson by 61
2017
Week 3
Clemson vs Louisville
Saturday, September 16th, 2017
CLEM 47, LOU 21
Cardinal Stadium
Clemson by 26

Team Standings

2021-2022 College Football Regular Season Standings - Clemson, Louisville
Team Conf Conf% W L PF PA Home Away Strk
#14 Clemson6-20.7501033421936-03-2W6
Louisville4-40.500674113554-32-2L2

Clemson & Louisville Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Clemson Championship Odds

No NCAA College Football Championship TM Clemson YR: futures available

Louisville Championship Odds

No NCAA College Football Championship TM Louisville YR: futures available

Clemson & Louisville Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2021-22 Clemson Games & Results
WeekMatchupDate & Result
Week 1Georgia vs
Clemson
UGA 10, CLEM 3
Saturday, September 4th, 2021
Week 2South Carolina State vs
Clemson
CLEM 49, SCST 3
Saturday, September 11th, 2021
Week 3Georgia Tech vs
Clemson
CLEM 14, GT 8
Saturday, September 18th, 2021
Week 4Clemson vs
NC State
NCST 27, CLEM 21 (2OT)
Saturday, September 25th, 2021
Week 5Boston College vs
Clemson
CLEM 19, BC 13
Saturday, October 2nd, 2021
Week 7Clemson vs
Syracuse
CLEM 17, SYR 14
Friday, October 15th, 2021
Week 8Clemson vs
Pittsburgh
PITT 27, CLEM 17
Saturday, October 23rd, 2021
Week 9Florida State vs
Clemson
CLEM 30, FSU 20
Saturday, October 30th, 2021
Week 10Clemson vs
Louisville
CLEM 30, LOU 24
Saturday, November 6th, 2021
Week 11UConn vs
Clemson
CLEM 44, CONN 7
Saturday, November 13th, 2021
Week 12Wake Forest vs
Clemson
CLEM 48, WAKE 27
Saturday, November 20th, 2021
Week 13Clemson vs
South Carolina
CLEM 30, SC 0
Saturday, November 27th, 2021
BowlsClemson vs
Iowa State
Cheez-It Bowl
CLEM 20, ISU 13
Wednesday, December 29th, 2021


2021-22 Louisville Games & Results
WeekMatchupDate & Result
Week 1Louisville vs
Ole Miss
MISS 43, LOU 24
Monday, September 6th, 2021
Week 2Eastern Kentucky vs
Louisville
LOU 30, EKU 3
Saturday, September 11th, 2021
Week 3UCF vs
Louisville
LOU 42, UCF 35
Friday, September 17th, 2021
Week 4Louisville vs
Florida State
LOU 31, FSU 23
Saturday, September 25th, 2021
Week 5Louisville vs
Wake Forest
WAKE 37, LOU 34
Saturday, October 2nd, 2021
Week 6Virginia vs
Louisville
UVA 34, LOU 33
Saturday, October 9th, 2021
Week 8Boston College vs
Louisville
LOU 28, BC 14
Saturday, October 23rd, 2021
Week 9Louisville vs
NC State
NCST 28, LOU 13
Saturday, October 30th, 2021
Week 10Clemson vs
Louisville
CLEM 30, LOU 24
Saturday, November 6th, 2021
Week 11Syracuse vs
Louisville
LOU 41, SYR 3
Saturday, November 13th, 2021
Week 12Louisville vs
Duke
LOU 62, DUKE 22
Thursday, November 18th, 2021
Week 13Kentucky vs
Louisville
UK 52, LOU 21
Saturday, November 27th, 2021
BowlsAir Force vs
Louisville
Servpro First Responder Bowl
AFA 31, LOU 28
Tuesday, December 28th, 2021

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Clemson vs Louisville College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 6th, 2021 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Clemson vs Louisville Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Clemson vs Louisville Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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