St. Louis Cardinals vs Cleveland Guardians Odds

The Cardinals will play the Guardians on Sunday, May 28th, 2023. Your timezone's first pitch time is 1:40 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Cardinals at Guardians Odds

**Best Moneyline Betting Odds**
Underdog Cleveland Guardians	Favorite St. Louis Cardinals
+115 BetMGM Bet	-140 BetMGM Bet

The St. Louis Cardinals are the -140 moneyline favorite. Risk $140 to win $100 on the St. Louis Cardinals at BetMGM. The Cleveland Guardians are the +115 underdog at BetMGM. Risk $100 to win $115 on the Cleveland Guardians. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
8.5 o -105 BetMGM Bet	8.5 u -115 BetMGM Bet

BetMGM has the best over line of 8.5 runs. Risk $105 to win $100. BetMGM has the best under line of 8.5 runs. Risk $115 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog Cleveland Guardians	Favorite St. Louis Cardinals
+1.5 -145 BetMGM Bet	-1.5 +120 BetMGM Bet

The St. Louis Cardinals have a -1.5 +120 run line at BetMGM OH. They are the run line favorite in this matchup. The Cleveland Guardians have a +1.5 -145 run line at BetMGM OH. The Cleveland Guardians are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs Cleveland Guardians MLB game on Sunday, May 28th, 2023?

The St. Louis Cardinals are the -140 moneyline favorite at BetMGM and the Cleveland Guardians are the +115 moneyline underdog at BetMGM.

What is the over-under total line for the St. Louis Cardinals vs Cleveland Guardians MLB game on Sunday, May 28th, 2023?

The best over line is 8.5 -105 runs at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 8.5 -115 runs at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the run line for the St. Louis Cardinals vs Cleveland Guardians MLB game on Sunday, May 28th, 2023?

The St. Louis Cardinals are -1.5 +120 run line favorites at BetMGM, while the Cleveland Guardians are +1.5 -145 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Cardinals Guardians 5/28/23 1:40pm EDT	-140 +115

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Possible Moneyline Outcomes

Cleveland Guardians bettors risk $100 to win $115 at +115 odds. The implied probability for Cleveland Guardians is 46.51%.
St. Louis Cardinals bettors risk $100 to win $71.43 at -140 odds. The implied probability for St. Louis Cardinals is 58.33%.

St. Louis Cardinals at Cleveland Guardians Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Cardinals Guardians First Team to Score 5/28/23 1:40pm EDT	-165 +130 Bet
Cardinals Guardians To Extra Innings 5/28/23 1:40pm EDT	Yes +750 No -1200 Bet
Cardinals Guardians 1st Team to Score Will Win 5/28/23 1:40pm EDT	Yes -250 No +190 Bet
Guardians Total Runs STL at CLE 5/28/23 1:40pm EDT	3.5 o -125 3.5 u -105 Bet
	BetMGM
Cardinals Total Runs STL at CLE 5/28/23 1:40pm EDT	4.5 o -105 4.5 u -125 Bet
Hunter Gaddis Strikeouts Thrown STL at CLE 5/28/23 1:40pm EDT	3.5 o -165 3.5 u +130 Bet

St. Louis Cardinals & Cleveland Guardians Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds

2025 St. Louis Cardinals World Series Odds
Team	BetMGM
Cardinals	+8000 Bet

Cleveland Guardians World Series Odds

2025 Cleveland Guardians World Series Odds
Team	BetMGM
Guardians	+2500 Bet

St. Louis Cardinals & Cleveland Guardians Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2023 MLB Regular Season Standings - St. Louis Cardinals, Cleveland Guardians
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
e - Cleveland Guardians	76	86	0.469	+28.0	42-39	34-47	662	697	-35	L2	4-6
e - St. Louis Cardinals	71	91	0.438	+33.0	35-46	36-45	719	829	-110	W2	4-6

How to Bet on the Game

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How to Bet on the St. Louis Cardinals vs Cleveland Guardians MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, May 28th, 2023 at 1:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Cleveland Guardians Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Cleveland Guardians Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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