Houston Astros vs St. Louis Cardinals Odds

The Astros will play the Cardinals on Wednesday, April 16th, 2025. Your timezone's first pitch time is 1:15 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


Bonus
BetMGM Sportsbook#1 BetMGM
REVIEW
New Customers - Up to $1500 Paid Back in Bonus Bets
Bonus Bets Expire in 7 Days
One new customer offer/Add'l Terms

Bet Now
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Houston Astros have a 90.67 power ranking. The power ranking for the St. Louis Cardinals is 93.67.
  • Visiting Houston Astros - The Houston Astros have a 3-4 record as a visiting team, ranking them 6th Overall for visiting team wins.
  • Home St. Louis Cardinals - The St. Louis Cardinals have a 7-3 record as a home team. They rank 3rd for home team wins in the Overall standings.
  • Runs Scored - The Houston Astros currently stand 17th (63) Overall, with the St. Louis Cardinals ranking 3rd (90) for runs scored.
  • Runs Allowed - The Houston Astros are 14th (66) Overall for runs allowed. The St. Louis Cardinals stand 5th (81) for runs allowed.
  • Team Streaks - The Houston Astros lost their last game. Meanwhile, the St. Louis Cardinals have won their last 2 games.
  • Team Records - The Houston Astros have a 7-9 Overall record (2.5 GB American West Division), with the St. Louis Cardinals possessing a 8-8 Overall standing (1.5 GB National Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye mateys! The Astros be facing the Cardinals in their den...

Houston be strugglin' with a record below 0.500... (Arrr, it be shameful!)

But fear not, me hearties, for the Cardinals be only slightly better... (Aye, just barely!)

If ye be feelin' lucky, head to SportsBetting3.com... bet on this game... and review the odds below. May the best team prevail on the diamond!

Best Astros at Cardinals Odds


Best Moneyline Betting Odds
Underdog

St. Louis Cardinals
Favorite

Houston Astros
The Houston Astros are the -110 moneyline favorite. Risk $110 to win $100 on the Houston Astros at BetMGM. The St. Louis Cardinals are the -110 underdog at BetMGM. Risk $110 to win $100 on the St. Louis Cardinals. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8 runs. Risk $118 to win $100. BetMGM has the best under line of 8 runs. Risk $102 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

St. Louis Cardinals
Favorite

Houston Astros
The Houston Astros have a -1.5 +155 run line at BetMGM OH. They are the run line favorite in this matchup. The St. Louis Cardinals have a +1.5 -190 run line at BetMGM OH. The St. Louis Cardinals are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Houston Astros vs St. Louis Cardinals MLB game on Wednesday, April 16th, 2025?

The Houston Astros are the -110 moneyline favorite at BetMGM and the St. Louis Cardinals are the -110 moneyline underdog at BetMGM.

What is the over-under total line for the Houston Astros vs St. Louis Cardinals MLB game on Wednesday, April 16th, 2025?

The best over line is 8 -118 runs at BetMGM, which means you risk $118 to win $100 betting the over. The best under line is 8 -102 runs at BetMGM, and that means you risk $102 to win $100 betting the under.

What is the run line for the Houston Astros vs St. Louis Cardinals MLB game on Wednesday, April 16th, 2025?

The Houston Astros are -1.5 +155 run line favorites at BetMGM, while the St. Louis Cardinals are +1.5 -190 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Astros
Cardinals
4/16/25 1:15pm EDT
-110-110
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966
Possible Moneyline Outcomes
  • St. Louis Cardinals bettors risk $100 to win $90.91 at -110 odds. The implied probability for St. Louis Cardinals is 52.38%.
  • Houston Astros bettors risk $100 to win $90.91 at -110 odds. The implied probability for Houston Astros is 52.38%.

Houston Astros at St. Louis Cardinals Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Astros
Cardinals
First Team to Score
4/16/25 1:15pm EDT
-155+120Bet
Astros
Cardinals
Tie
1st Inning Winner
4/16/25 1:15pm EDT
+290+280-130Bet
Astros
Cardinals
Tie
First 3 Innings Winner
4/16/25 1:15pm EDT
+140+135+300Bet
Astros
Cardinals
To Extra Innings
4/16/25 1:15pm EDT
Yes +750No -1200Bet
BetMGM Sports Betting BetMGM
Astros
Cardinals
1st Team to Score Will Win
4/16/25 1:15pm EDT
Yes -250No +190Bet
Astros
Total Runs
HOU at STL
4/16/25 1:15pm EDT
3.5 o -1453.5 u +110Bet
Cardinals
Total Runs
HOU at STL
4/16/25 1:15pm EDT
3.5 o -1403.5 u +105Bet
Ronel Blanco
Strikeouts Thrown
HOU at STL
4/16/25 1:15pm EDT
4.5 o -1404.5 u +105Bet

Houston Astros & St. Louis Cardinals Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Houston Astros World Series Odds
2025 Houston Astros World Series Odds

Team
BetMGM Sports Betting BetMGM
Astros
+2200
Bet
St. Louis Cardinals World Series Odds
2025 St. Louis Cardinals World Series Odds

Team
BetMGM Sports Betting BetMGM
Cardinals
+12500
Bet

Houston Astros & St. Louis Cardinals Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Houston Astros, St. Louis Cardinals
Team W L Pct GB Home Away RS RA Diff Strk L10
Houston Astros13110.542+4.59-64-59281+11W37-3
St. Louis Cardinals10150.400+8.08-42-11120118+2L13-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Houston Astros vs St. Louis Cardinals MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, April 16th, 2025 at 1:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Houston Astros vs St. Louis Cardinals Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs St. Louis Cardinals Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other April 16, 2025 MLB Games

Odds Preview 12168