Houston Astros vs San Diego Padres Odds

The Astros will play the Padres on Wednesday, September 18th, 2024. Your timezone's first pitch time is 6:40 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Astros at Padres Odds

**Best Moneyline Betting Odds**
Underdog Houston Astros	Favorite San Diego Padres
-105 BetMGM Bet	-115 BetMGM Bet

The San Diego Padres are the -115 moneyline favorite. Risk $115 to win $100 on the San Diego Padres at BetMGM. The Houston Astros are the -105 underdog at BetMGM. Risk $105 to win $100 on the Houston Astros. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
6.5 o -120 BetMGM Bet	6.5 u +100 BetMGM Bet

BetMGM has the best over line of 6.5 runs. Risk $120 to win $100. BetMGM has the best under line of 6.5 runs. Risk $100 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog San Diego Padres	Favorite Houston Astros
+1.5 -210 BetMGM Bet	-1.5 +170 BetMGM Bet

The Houston Astros have a -1.5 +170 run line at BetMGM OH. They are the run line favorite in this matchup. The San Diego Padres have a +1.5 -210 run line at BetMGM OH. The San Diego Padres are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Houston Astros vs San Diego Padres MLB game on Wednesday, September 18th, 2024?

The San Diego Padres are the -115 moneyline favorite at BetMGM and the Houston Astros are the -105 moneyline underdog at BetMGM.

What is the over-under total line for the Houston Astros vs San Diego Padres MLB game on Wednesday, September 18th, 2024?

The best over line is 6.5 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 6.5 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.

What is the run line for the Houston Astros vs San Diego Padres MLB game on Wednesday, September 18th, 2024?

The Houston Astros are -1.5 +170 run line favorites at BetMGM, while the San Diego Padres are +1.5 -210 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Astros Padres 9/18/24 6:40pm EDT	-105 -115

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Possible Moneyline Outcomes

Houston Astros bettors risk $100 to win $95.24 at -105 odds. The implied probability for Houston Astros is 51.22%.
San Diego Padres bettors risk $100 to win $86.96 at -115 odds. The implied probability for San Diego Padres is 53.49%.

Houston Astros at San Diego Padres Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Astros Padres First Team to Score 9/18/24 6:40pm EDT	-140 +110 Bet
Astros Padres Tie 1st Inning Winner 9/18/24 6:40pm EDT	+350 +325 -165 Bet
Astros Padres Tie First 3 Innings Winner 9/18/24 6:40pm EDT	+170 +140 +225 Bet
Astros Padres To Extra Innings 9/18/24 6:40pm EDT	Yes +650 No -1100 Bet
	BetMGM
Astros Padres 1st Team to Score Will Win 9/18/24 6:40pm EDT	Yes -250 No +190 Bet
Astros Total Runs HOU at SDG 9/18/24 6:40pm EDT	3.5 o +110 3.5 u -145 Bet
Padres Total Runs HOU at SDG 9/18/24 6:40pm EDT	3.5 o +115 3.5 u -150 Bet
Dylan Cease Strikeouts Thrown HOU at SDG 9/18/24 6:40pm EDT	5.5 o -155 5.5 u +115 Bet
	BetMGM
Framber Valdez Strikeouts Thrown HOU at SDG 9/18/24 6:40pm EDT	5.5 o +100 5.5 u -130 Bet

Houston Astros & San Diego Padres Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Houston Astros World Series Odds

2025 Houston Astros World Series Odds
Team	BetMGM
Astros	+1400 Bet

San Diego Padres World Series Odds

2025 San Diego Padres World Series Odds
Team	BetMGM
Padres	+1400 Bet

Houston Astros & San Diego Padres Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2024 MLB Regular Season Standings - Houston Astros, San Diego Padres
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
y - San Diego Padres	93	69	0.574	+5.0	45-36	48-33	760	669	+91	L1	7-3
x - Houston Astros	88	73	0.547	+9.5	46-35	42-38	740	649	+91	W2	6-4

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Houston Astros vs San Diego Padres MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, September 18th, 2024 at 6:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Houston Astros vs San Diego Padres Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs San Diego Padres Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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