The Bills will play the Lions on Thursday, November 24th, 2022. The matchup takes place at Ford Field. Watch this exciting Week 12 matchup at 12:30 pm EST. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Best Bills at Lions Odds
| Underdog Detroit Lions | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog Detroit Lions | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -9.5 -110 point spread favorites at BetMGM, while the Detroit Lions are +9.5 -110 point spread underdogs at BetMGM.
The best over line is 54.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 54.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Buffalo Bills are the -450 moneyline favorite at BetMGM and the Detroit Lions are the +350 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Bills
Lions
11/24/22 12:30pm EST | -9.5 -110+9.5 -110 |
Underdog Detroit Lions - Detroit Lions bettors risk $100 to win $90.91 at -110 odds.
A +9.5 Detroit Lions underdog bet wins if they lose by 9 or fewer, tie, or win outright. Your bet loses if they lose by 10 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $90.91 at -110 odds.
A -9.5 Buffalo Bills favorite bet wins if they win by 10 or more. Your bet loses if they win by 9 or fewer, tie, or lose outright.
Buffalo Bills at Detroit Lions Prop Bets
| BetMGM Bet |
|
|---|---|
Bills
Lions
11/24/22 12:30pm EST | Pending BetMGM |
Recent Meetings Since 2018
| Week | Game | Result | Margin |
|---|---|---|---|
| 2022 Week 12 | Bills vs Lions Thursday, November 24th, 2022 | BUF 28, DET 25 Ford Field | Bills by 3 |
| 2021 Preseason Week 1 | Bills vs Lions Friday, August 13th, 2021 | BUF 16, DET 15 Ford Field | Bills by 1 |
| 2019 Preseason Week 3 | Bills vs Lions Friday, August 23rd, 2019 | BUF 24, DET 20 Ford Field | Bills by 4 |
| 2018 Week 15 | Lions vs Bills Sunday, December 16th, 2018 | BUF 14, DET 13 Highmark Stadium | Bills by 1 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 13 | 3 | 0 | 0.813 | 455 | 286 | 7-1-0 | 6-2-0 | 4-2-0 | 0.667 | 9-2-0 | 0.818 | 7W | 5-0-0 |
| Detroit Lions | 9 | 8 | 0 | 0.529 | 453 | 427 | 5-4-0 | 4-4-0 | 5-1-0 | 0.833 | 7-5-0 | 0.583 | 2W | 4-1-0 |
Buffalo Bills & Detroit Lions Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Buffalo Bills Futures Odds|
Team | BetMGM |
|---|---|
| Bills | +650 Bet |
|
Team | BetMGM |
|---|---|
| Lions | +310 Bet |
Buffalo Bills & Detroit Lions Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Buffalo Bills vs Detroit Lions NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Thursday, November 24th, 2022 at 12:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Buffalo Bills vs Detroit Lions Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Buffalo Bills vs Detroit Lions Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.