The 49ers will play the Bills on Sunday, December 1st, 2024. The matchup takes place at Highmark Stadium. Watch this exciting Week 13 matchup at 8:20 pm EST. Check local listings for coverage on NBC, Peacock.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 13, as the 2024-25 NFL regular season is coming to a close. This week's action includes a matchup between the San Francisco 49ers and Buffalo Bills. They'll play on Sunday, December 1st, 2024 at Highmark Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 13 of the 2024-25 NFL regular season, the San Francisco 49ers have a 89.33 power ranking based on our formula. Their opponent, the Buffalo Bills, currently possess a 98.67 power ranking.
- Away San Francisco 49ers - With the season coming to a close, the San Francisco 49ers have a 2-3-0 record as an away team, ranking them 5th in the league for away team wins.
- Home Buffalo Bills - The Buffalo Bills come to this Week 13 game with a 5-0-0 record as a home team. They rank 1st in the league for home team wins as the 2024-25 regular season wraps up.
- Points Scored - The San Francisco 49ers currently rank 14th (260) headed into Week 13, with the Buffalo Bills ranked 4th (320) for points scored to date.
- Points Against - As the regular season winds down, the San Francisco 49ers rank 15th (260) for points score against them. Note that the Buffalo Bills now rank 23rd (214) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 13, the San Francisco 49ers have a 5-6-0 record, with the Buffalo Bills at 9-2-0 for the 2024-25 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The 49ers sail to Buffalo to plunder victory on Sunday!
Ye NFL regular season be near over, this match may change the playoff picture.
With a 5-6-0 record, the 49ers challenge the Bills who stand at 9-2-0.
This fierce battle be held at Highmark Stadium, where the Bills aim to defend their turf.
According to SportsBetting3.com, the Bills rank higher at 98.67 compared to the 49ers' 89.33.
Place a bet at BetRivers or BetMGM, and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks.
Best 49ers at Bills Odds
| Underdog San Francisco 49ers | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -6.5 -115 point spread favorites at BetMGM, while the San Francisco 49ers are +6.5 -105 point spread underdogs at BetMGM.
The best over line is 45 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 45 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Buffalo Bills are the -350 moneyline favorite at BetMGM and the San Francisco 49ers are the +260 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Bills
12/01/24 8:20pm EST | +6.5 -105-6.5 -115 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $95.24 at -105 odds.
A +6.5 San Francisco 49ers underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $86.96 at -115 odds.
A -6.5 Buffalo Bills favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.
San Francisco 49ers at Buffalo Bills Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Bills
First Team To Score
12/01/24 8:20pm EST | +125-160Bet |
49ers
Bills
No Touchdown
To Score 1st Touchdown
12/01/24 8:20pm EST | +150-200+10000Bet |
49ers
Bills
Game to Overtime
12/01/24 8:20pm EST | Yes +800No -3000Bet |
49ers
Bills
Safety to be Scored
12/01/24 8:20pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
SF at BUF 12/01/24 8:20pm EST | 0.5 o -1100.5 u -120Bet |
Josh Allen
Interceptions Thrown
SF at BUF 12/01/24 8:20pm EST | 0.5 o -1050.5 u -125Bet |
Brock Purdy
Longest Passing Completion
SF at BUF 12/01/24 8:20pm EST | 32.5 o -12032.5 u -110Bet |
Josh Allen
Longest Passing Completion
SF at BUF 12/01/24 8:20pm EST | 34.5 o -12034.5 u -110Bet |
| BetMGM | |
Jake Moody
Total Kicking Points
SF at BUF 12/01/24 8:20pm EST | 5.5 o -1305.5 u +100Bet |
Tyler Bass
Total Kicking Points
SF at BUF 12/01/24 8:20pm EST | 6.5 o -1406.5 u +105Bet |
Brock Purdy
Total Pass Completions
SF at BUF 12/01/24 8:20pm EST | 19.5 o -10519.5 u -125Bet |
Josh Allen
Total Pass Completions
SF at BUF 12/01/24 8:20pm EST | 20.5 o -10520.5 u -125Bet |
| BetMGM | |
Brock Purdy
Total Passing Yards
SF at BUF 12/01/24 8:20pm EST | 213.5 o -115213.5 u -115Bet |
Josh Allen
Total Passing Yards
SF at BUF 12/01/24 8:20pm EST | 218.5 o -115218.5 u -115Bet |
Brock Purdy
Total Touchdown Passes
SF at BUF 12/01/24 8:20pm EST | 1.5 o +1501.5 u -210Bet |
Josh Allen
Total Touchdown Passes
SF at BUF 12/01/24 8:20pm EST | 1.5 o +1101.5 u -145Bet |
Recent Meetings Since 2020
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Week 13 | 49ers vs Bills Sunday, December 1st, 2024 | BUF 35, SF 10 Highmark Stadium | Bills by 25 |
| 2020 Week 13 | Bills vs 49ers Monday, December 7th, 2020 | BUF 34, SF 24 State Farm Stadium | Bills by 10 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 12 | 3 | 0 | 0.800 | 469 | 331 | 7-0-0 | 5-3-0 | 4-0-0 | 1.000 | 8-2-0 | 0.800 | 2W | 4-1-0 |
| San Francisco 49ers | 6 | 9 | 0 | 0.400 | 331 | 349 | 4-4-0 | 2-5-0 | 1-4-0 | 0.200 | 4-6-0 | 0.400 | 2L | 1-4-0 |
San Francisco 49ers & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures OddsNo Super Bowl TM San Francisco 49ers YR: futures available
Buffalo Bills Futures Odds|
Team | BetMGM |
|---|---|
| Bills | +550 Bet |
San Francisco 49ers & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 1st, 2024 at 8:20 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other December 1, 2024 NFL Games
- Los Angeles Chargers vs Atlanta Falcons
- Pittsburgh Steelers vs Cincinnati Bengals
- Houston Texans vs Jacksonville Jaguars
- Arizona Cardinals vs Minnesota Vikings
- Tennessee Titans vs Washington Commanders
- Seattle Seahawks vs New York Jets
- Indianapolis Colts vs New England Patriots
- Tampa Bay Buccaneers vs Carolina Panthers
- Los Angeles Rams vs New Orleans Saints
- Philadelphia Eagles vs Baltimore Ravens